BIOCHEMICAL AND IMMUNOHISTOCHEMICAL STUDIES OF MATRIX METALLOPROTEINASES IN PERIODONTAL DISEASE PATHOGENESIS AFFECTING CHILDREN WITH CONNECTIVE TISSUE DYSPLASIA SYNDROME

The interest taken in studying pathomorphological and pathophysiological mechanisms behind periodontal inflammation affecting children with undifferentiated connective tissue dysplasia (UCTD) can be accounted for by the disease high prevalence, risk of its progression, as well morphological functional immaturity tissues low effectiveness available treatment options. study into matrix metalloproteinases (MMPs) expression gum oral fluid biopsy material UCTD is both scientific practical value terms diagnostic identification, course assessment, design individualized modes diseases. In order to determine specific features MMP-2, MMP-8, MMP-9 expression, our involved 61 diseases various degrees UCTD, 27 healthy intact periodontium. implied analyzing participants’ immune-histochemical studies enzyme immunoassay results. MMP concentration revealed that a prominent degree had their (medians 5.49 ng/ml, 478.4 921.6 respectively) exceeding significantly these enzymes whose could described mild 2.76 317.1 584.3 respectively). An analysis showed MMP-2 not reliable indicator offer data required assess clinical status tissues, since it detected periodontium syndrome. MMP-8 provide an objective description active phase inflammation, which means should considered biomarkers activity at manifestation stage. Biochemical immunohistochemical syndrome used identify structural status, nature detect potential groups vulnerable development diseases, evaluate schemes comprehensive issues.